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Cytochroma P450 CYP1A2 (-atis, n.) (Numerus EC: 1.14.14.1) est haemoproteinum et pars gregis Cytochroma P450 ideo in metabolismo Coffeini (Coffeum, Thea, Cola, Mate, Paullinia cupana/Guaraná, energy drink) et oestrogenorum interest.

Cytochroma P450 CYP1A2.

Expressio geni CYP1A2 brassicis et tabaco et medicamento Omeprazoli (inductores) aucta est.

Cuminum et Curcuma et Hypericum Perforatum et Malum paradisi et antibioticum Ciprofloxacini (inhibitores) haemoproteinum CYP1A2 inhibent.

Fieri potest ut functio aucta CYP1A2 periculo aucto cancri mammae praesit[1]

Pharmaca ad CYP1A2 relata

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Multa antidepressiva substratum cytochromatis 1A2 sunt. Inhibitores ut ciprofloxacinum (antibioticum) effectus substratorum augere possunt.

Pharmaca relata ad CYP1A2[2][3].
Substrati Inhibitores[4] Inductores[5]
  1. Hong CC, Tang BK, Rao V, Agarwal S, Martin L, Tritchler M, Yaffe M, Boyd NF (2004). Cytochrome P450 1A2 (CYP1A2) activity, mammographic density, and oxidative stress: a cross-sectional study. Breast Cancer Res 6: 7, pp. 338–351 http://download.springer.com/static/pdf/139/art%253A10.1186%252Fbcr797.pdf?originUrl=http%3A%2F%2Fbreast-cancer-research.biomedcentral.com%2Farticle%2F10.1186%2Fbcr797&token2=exp=1482277547~acl=%2Fstatic%2Fpdf%2F139%2Fart%25253A10.1186%25252Fbcr797.pdf*~hmac=088fe1b55e95e49a9e798c6dbb6af0466e5327eec218fba5763fe045d52662ae[nexus deficit]
  2. Cozza KL, Armstrong SC (2001). The Cytochrome P450 System. Drug Interaction Principles for Medical Practice. Washington, DC: American Psychiatric Publishing
  3. Preskorn SH (1996). Clinical Pharmacology of Selective Serotonin Reuptake Inhibitors. 1st ed.: Professional Communications, Inc.
  4. Inhibitor cum subtratorum effectibus fortioribus
  5. Inductor cum subtratorum effectibus minoribus
  6. Metabolismus CYP1A2 lentior quam CYP2D6
  7. Anglice: Warfarin, WARF = Wisconsin Alumni Research Foundation; -arin: ex Coumarin derivatur
  8. Cho T. M., Rose R. L., Hodgson E. (2006). "In vitro metabolism of naphthalene by human liver microsomal cytochrome P450 enzymes". Drug metabolism and disposition 34 (1): 176-83 
  9. 9.0 9.1 9.2 9.3 homines cum effectibus variis cytochromati CYP1A2 (Anglice)

Nexus externi

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