Dopaminum
| Cognitores | |
|---|---|
| ChemSpider | 661 |
| PubChem | 681 |
| DrugBank | DB00988 |
| Natura chemica | |
| |
| |
| Formula summarum | C 8H 11NO 2 |
| Massa molaris | 153.181 g/mol |
Dopaminum est compositum organicum et neurotransmissor in cerebro, quo munera systematum et remunerationis et extrapyramidalis (motuum) habet.
In nonnullis cerebri structuris dopaminum abunde invenitur, ut in substantia nigra. Inopia dopamini morbo Parkinson signum morbi proprium attribuebatur.
Receptoria neurotransmissoris quae ad dopaminum spectant, dopaminergica nominantur.
Natura chemicaRecensere
Nomen IUPAC est 4-(2-amino-aethyl)-benzino-1,2-diolum. Simul est catecholaminum, quare dopamini greges et catecholi et amini insunt.
Phenyl-aethyl-aminum
BiochemiaRecensere
Dopaminum per enzymum dopamini beta-hydroxylasis in neurotransmissorem noradrenalinum transvertitur.
PhysiologiaRecensere
In organismo dopaminum est et hormon et neurotransmissor.[1] Synthesis imprimis ex aminoacido phenylalanini fit, quod per aminoacida ipsa tyrosini et laevodopa (L-DOPA, 3,4-dihydroxyphenylalaninum) in dopaminum convertitur. Degradatio dopamini per enzyma MAO-B et COMT fit.
Dopaminum neurotransmissorRecensere
In systematis nervosi centralis dopaminum est neurotransmissor, quae receptoria dopaminergica, ut D2 obsidet. Liberatur dopaminum de neuronibus substantiae nigrae et areae tegmentalis ventralis.
NotaeRecensere
- ↑ Franco R., Reyes-Resina I., Navarro G. (Ian 2021). "Dopamine in Health and Disease: Much More Than a Neurotransmitter". Biomedicines 9 (2): 109.