Dopamina
| Cognitores | |
|---|---|
| ChemSpider | 661 |
| PubChem | 681 |
| DrugBank | DB00988 |
| Natura chemica | |
| |
| |
| Formula summarum | C 8H 11NO 2 |
| Massa molaris | 153.181 g/mol |
Dopamina[1][2] est compositum organicum et neurotransmissor in cerebro, quo munera systematum et remunerationis et extrapyramidalis (motuum) habet.
In nonnullis cerebri structuris dopamina abunde invenitur, ut in substantia nigra. Inopia dopaminae morbo Parkinson signum morbi proprium attribuebatur.
Receptoria neurotransmissoris quae ad dopaminam spectant, dopaminergica nominantur.
Natura chemicaRecensere
Nomen IUPAC est 4-(2-amino-aethyl)-benzino-1,2-diolum. Simul est catecholaminum, quare dopaminae greges et catecholi et aminae insunt.
Phenyl-aethyl-aminum
BiochemiaRecensere
Dopamina per enzymum dopamini beta-hydroxylasis in neurotransmissorem noradrenalinam transvertitur.
PhysiologiaRecensere
In organismo, dopamina est et hormon et neurotransmissor.[3] Synthesis imprimis ex aminoacido phenylalaninae fit, quod per aminoacida ipsa tyrosinae et laevodopa (L-DOPA, 3,4-dihydroxyphenylalanina) in dopaminam convertitur. Degradatio dopaminae per enzyma MAO-B et COMT fit.
Dopamina neurotransmissorRecensere
In systematis nervosi centralis dopamina est neurotransmissor, quae receptoria dopaminergica, ut D2 obsidet. Liberatur dopamina de neuronibus substantiae nigrae et areae tegmentalis ventralis.
NotaeRecensere
- ↑ Cfr. "Dopaminae-β hydroxylase (DBH) ...", apud Vogt, Brent A.; Hof, Patrick R.; Friedman, David P.; Sikes, Robert W.; Vogt, Leslie J. (4 Martiis 2008). "Norepinephrinergic Afferents and Cytology of the Macaque Monkey Midline, Mediodorsal, and Intralaminar Thalamic Nuclei". Brain Structure and Function 212 (6): 465–479
- ↑ Fortasse vide etiam "dopaminae" apud (p. 11) Universitas Neapolitana (2022). "Integrated Course of Medical Pharmacology and Toxicology II"
- ↑ Franco R., Reyes-Resina I., Navarro G. (Ian 2021). "Dopamine in Health and Disease: Much More Than a Neurotransmitter". Biomedicines 9 (2): 109.