Monoaminorum oxidasis B
Monoaminorum oxidasis B (abbreviatura MAO-B) est unum ex duobus isoenzymis monoaminorum oxidasis (OMIM: 309860). Nomen chromosomate X locati geni est MAOB.
Natura MAO-B recensere
Genum MAOB in chromosomate X (Xp11.3) locatum est. In cerebro humano MAO-B praecipue in cellulis nervorum systematis serotonergici atque nucleis raphes (et dorsalibus et medianis) inventum est[1]. Enzymum MAO-B in thrombocytis quoque exprimuntur.
Effectus MAO-B recensere
Enzym hoc decompositionem dopamini perficit. Inhibito igitur enzymi multitudinem dopamini augeat.
Inhibitores MAO-B recensere
Inhibitores sunt Rasagilinum, Safinamidum[2], Selegilinum. Fumatio quoque MAO-B inhibit[3].
| Medicamentum | t½ |
|---|---|
| Rasagilinum | 3 h |
| Selegilinum | 10 h |
| Safinamidum | 20-30 h |
Notae recensere
- ↑ Westlund K. N., Denney R. M., Rose R. M., Abell C. W. (1988). "Localization of distinct monoamine oxidase A and monoamine oxidase B cell populations in human brainstem". Neuroscience 25 (2): 439-56
- ↑ Stocchi F., Arnold G., Onofrj M., Kwiecinski H., Szczudlik A., Thomas A., Bonuccelli U., Van Dijk A., Cattaneo C., Sala P., Fariello R. G.; Safinamide Parkinson's Study Group (2004). "Improvement of motor function in early Parkinson disease by safinamide". Neurology 63 (4): 746-8
- ↑ Fowler J. S., Volkow N. D., Wang G. J., Pappas N., Logan J., MacGregor R., Alexoff D., Shea C., Schlyer D., Wolf A. P., Warner D., Zezulkova I., Cilento R. (1996). "Inhibition of monoamine oxidase B in the brains of smokers". Nature 379 (6567): 733-6