Area tegmentalis ventralis

Area tegmentalis ventralis

Area tegmentalis in mesencephalo locata est.

Area tegmentalis ventralis (VTA) cum substantia nigra

Area tegmentalis ventralis (TA: 14.1.06.007) (abbreviatura internationalis VTA) mesencephali est grex neuronorum A10 et initium itineris mesocorticolimbici ad corticem praefrontalem. Neurotransmissor est dopaminum. Parti systematis remunerationis areae tegmentali ventrali munera cognitionis, motivationis, orgasmi sunt^[1].

Anatomia

Area tegmentalis ventralis in gregres anteriorem et posteriorem dividitur. Insunt:

Area parafasciculi retroflexi
Area parabrachialis
Nucleus parainterfascicularis
Nucleus paranigralis
Cauda areae tegmentalis ventralis (= nucleus tegmentalis rostromedialis)

Physiologia

Itinera afferentia

Receptoria et GABA (GABAA) et adrenergica α₁ (α1-AR) responsa VTA movent^[2]. Indita in aream tegmentalem ventralem per fasciculum telencephalicum medialem ab nucleis septalibus, in parte post transmissionem in nucleo praeoptico, immergunt.

Itinera efferentia

Axones in corticem praefrontalem^[3], gyrum cinguli, hippocampum, nucleum accumbentem, bulbum olfactorium, amygdalam prodeunt.

Tractus mesolimbicus

Conferatur pagina principalis Tractus mesolimbicus.

Tractus mesolimbicus est coniunctio dopaminergica inter aream tegmentalem ventralem et nucleum accumbentem, corticem praefrontalem, nucleum caudatum, bulbum olfactorium, hippocampum, et corpus amygdaloideum.

Notae

↑ Holly E. N., Miczek K. A. (2016). "Ventral tegmental area dopamine revisited: effects of acute and repeated stress". Psychopharmacology (Berl) 233 (2): 163-86
↑ Velásquez-Martínez M. C., Vázquez-Torres R., Rojas L. V., Sanabria P., Jiménez-Rivera C. A. (2015). "Alpha-1 adrenoreceptors modulate GABA release onto ventral tegmental area dopamine neurons". Neuropharmacology 88: 110-21
↑ Puig M. V., Antzoulatos E. G., Miller E. K. (2014). "Prefrontal dopamine in associative learning and memory". Neuroscience 282: 217-29

Nexus interni

[1] Holly E. N., Miczek K. A. (2016). "Ventral tegmental area dopamine revisited: effects of acute and repeated stress". Psychopharmacology (Berl) 233 (2): 163-86

[2] Velásquez-Martínez M. C., Vázquez-Torres R., Rojas L. V., Sanabria P., Jiménez-Rivera C. A. (2015). "Alpha-1 adrenoreceptors modulate GABA release onto ventral tegmental area dopamine neurons". Neuropharmacology 88: 110-21

[3] Puig M. V., Antzoulatos E. G., Miller E. K. (2014). "Prefrontal dopamine in associative learning and memory". Neuroscience 282: 217-29

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