Enzymum angiotensinum convertens 2
| Enzymum angiotensinum convertens 2 ACE2 | |||||
|---|---|---|---|---|---|
| Cognitores | |||||
| Alia nomina | ACE2, ACEH | ||||
| Numerus EC | 3.4.17.23 (hydrolasis) | ||||
| Fontes externae | OMIM: 300335 | ||||
| Genetica | |||||
| Locus geni (homo) | |||||
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 | |||||
| Locus | Xp22.2 | ||||
| Initium | 15 561 033 | ||||
| Terminus | 15 602 148 | ||||
| Biochemia | |||||
| Substratum | Proangiotensinum (angiotensinum I) | ||||
Enzymum angiotensinum convertens 2 (ACE2) (numerus EC: 3.4.17.23) est enzymum, quod proangiotensinum (seu angiotensinum I) in angiotensinum (1-7) convertit.
Enzymum praecipue in cellulis endothelialibus cordis renumque exprimitur.
Enzymum angiotensinum convertens 2 est scopus viri SARS-CoV-2 (coronaviri novi), at non medicamentorum ut inhibitorum enzymi angiotensinum convertentis.
Genetica
recensereGenum enzymi angiotensinum convertentis, ACE2 nominatum, in hominibus in chromosomate X invenitur.
Effectus enzymi physiologicus
recensereEnzymum angiotensinum convertens 2 proangiotensinum (angiotensinum I) in angiotensinum (1-7) convertit[1].
Angiotensini
recensereAngiotensini est grex hormonum peptidorum. Ex angiotensinogeno praecursore hormonum (prohormone; sine effectu physiologico) in iecore ob hormon renini angiotensinum I generatur. Imprimis in pulmonibus angiotensinum I in angiotensinum II ob enzymum angiotensinum convertens (ACE) convertitur.
ACE2 porta intrandi viri SARS-CoV-2
recensereSARS-coronaviri receptorium ad enzymum ACE2 appellunt[2].
Nexus interni
Notae
recensere- ↑ Keidar S., Kaplan M., Gamliel-Lazarovich A. (Feb 2007). "ACE2 of the heart: From angiotensin I to angiotensin (1-7)". Cardiovascular Research 73 (3): 463-9
- ↑ Inoue Y., Tanaka N., Tanaka Y., Inoue S., Morita K., Zhuang M., Hattori T., Sugamura K. (Aug 2007). "Clathrin-dependent entry of severe acute respiratory syndrome coronavirus into target cells expressing ACE2 with the cytoplasmic tail deleted". Journal of Virology 81 (16): 8722-9
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