Receptorium acetylcholini muscarinicum M1

Receptorium M₁
Alia nomina	M1R
Locus geni (homo)

Chromosoma	11 (humanum)
Locus	11q12.3 (homo)
Fontes externae	OMIM: 118510

Receptorium acetylcholini M₁ (M1R) est receptorium muscarinium et proteino G copulatum. In hominibus genum eius in chromosomate 11 locatum est. Nomen geni est CHRM1.

Receptoria M₁ imprimis in systemate nervoso centrali inveniuntur, quare ea subtypi neuronales vocitantur^[1].

Multae antagonistae notae sunt, inter eas etiam medicamenta ut Olanzapinum, Quetiapinum.

Physiologia

M1 muscarinicum acetylcholini receptorium (M1 mAChR) cum proteino Gα_q coniuncta sunt^[2], receptorium proteino G copulatum. Stimulatum quasdam kinases ut proteini kinases C (PKC) et A (PKA), velut GPTases parvas (RAS, proteinum G parvum) incitat. Ita activatae et proteini kinases et GPTases epitonia molecularia quoque agunt.

Proteina G, proteinum Gα et subunitas q suum

Conferatur pagina principalis Proteinum G.

Inveniuntur heterotrimerica (subunitatibus α, β, γ) proteina cum Gα superficie interna intracellulari^[3]. Proteina G epitonia molecularia simplicia videri possunt: Stimulatum enim proteinum statum suum brevis temporis mutant. Dissoluta ab heterodimericis subunitatibus β et γ, subunitas α (Gα_q) communiter cum phospholipasi Cβ agit^[4].

Proteini kinases C (PKC) et A (PKA)

PKC sunt familia kinasum, quae proteinis positionibus aminoacidorum et serini et threonini greges phosphati dant. PKA prasentiae cyclici adenosini triphosphati (cAMP) pendet.

PKC serino grege HO phosphatum addit

In corpore distributio

Inveniuntur receptoria M₁

in glandulis salivariis, quamquam receptoria M₃ abundiora sunt^[5]

Notae

↑ Felder C. C., Goldsmith P. J., et al. (Iul 2018). "Current Status of Muscarinic M1 and M4 Receptors as Drug Targets for Neurodegenerative Diseases". Neuropharmacology 136: 449-58
↑ Chen M.-W., Zhu H., et al. (Mai 2020). "PKC and Ras are Involved in M1 Muscarinic Receptor-Mediated Modulation of AMPA Receptor GluA1 Subunit". Cellular and molecular neurobiology 40 (4): 547-54
↑ Lyon A. M., Taylor V. G., Tesmer J. J. G. (Ian 2014). "Strike a pose: Gαq complexes at the membrane". Trends in pharmacological sciences 35 (1): 23-30
↑ Sánchez-Fernández G., Cabezudo S., et al. (Mai 2014). "Gαq signalling: the new and the old". Cellular signalling 26 (5): 833-48
↑ Proctor G. B., Carpenter G. H. (2007). "Regulation of Salivary Gland Function by Autonomic Nerves". Autonomic neuroscience: basic & clinical 133 (1): 3-18

Nexus interni

stipula

Haec stipula ad biologiam spectat. Amplifica, si potes!

[1] Felder C. C., Goldsmith P. J., et al. (Iul 2018). "Current Status of Muscarinic M1 and M4 Receptors as Drug Targets for Neurodegenerative Diseases". Neuropharmacology 136: 449-58

[2] Chen M.-W., Zhu H., et al. (Mai 2020). "PKC and Ras are Involved in M1 Muscarinic Receptor-Mediated Modulation of AMPA Receptor GluA1 Subunit". Cellular and molecular neurobiology 40 (4): 547-54

[3] Lyon A. M., Taylor V. G., Tesmer J. J. G. (Ian 2014). "Strike a pose: Gαq complexes at the membrane". Trends in pharmacological sciences 35 (1): 23-30

[4] Sánchez-Fernández G., Cabezudo S., et al. (Mai 2014). "Gαq signalling: the new and the old". Cellular signalling 26 (5): 833-48

[5] Proctor G. B., Carpenter G. H. (2007). "Regulation of Salivary Gland Function by Autonomic Nerves". Autonomic neuroscience: basic & clinical 133 (1): 3-18

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