Receptorium acetylcholini muscarinicum M1

(Redirectum de CHRM1 (genum))
Receptorium M1
Alia nomina M1R
Locus geni (homo)
Chromosomate 11 locatum
Chromosoma 11 (humanum)
Locus 11q12.3 (homo)
Fontes externae OMIM: 118510

Receptorium acetylcholini M1 (M1R) est receptorium muscarinium et proteino G copulatum. In hominibus genum eius in chromosomate 11 locatum est. Nomen geni est CHRM1.

Receptoria M1 imprimis in systemate nervoso centrali inveniuntur, quare ea subtypi neuronales vocitantur[1].

Multae antagonistae notae sunt, inter eas etiam medicamenta ut Olanzapinum, Quetiapinum.

PhysiologiaRecensere

M1 muscarinicum acetylcholini receptorium (M1 mAChR) cum proteino Gαq coniuncta sunt[2], receptorium proteino G copulatum. Stimulatum quasdam kinases ut proteini kinases C (PKC) et A (PKA), velut GPTases parvas (RAS, proteinum G parvum) incitat. Ita activatae et proteini kinases et GPTases epitonia molecularia quoque agunt.

Proteina G, proteinum Gα et subunitas q suumRecensere

  Commentatio principalis: Proteinum G

Inveniuntur heterotrimerica (subunitatibus α, β, γ) proteina cum Gα superficie interna intracellulari[3]. Proteina G epitonia molecularia simplicia videri possunt: Stimulatum enim proteinum statum suum brevis temporis mutant. Dissoluta ab heterodimericis subunitatibus β et γ, subunitas α (Gαq) communiter cum phospholipasi Cβ agit[4].

Proteini kinases C (PKC) et A (PKA)Recensere

PKC sunt familia kinasum, quae proteinis positionibus aminoacidorum et serinum et threonini greges phosphati dant. PKA prasentiae cyclici adenosini triphosphati (cAMP) pendet.

In corpore distributioRecensere

Inveniuntur receptoria M1

NotaeRecensere

  1. Felder C. C., Goldsmith P. J., et al. (Iul 2018). "Current Status of Muscarinic M1 and M4 Receptors as Drug Targets for Neurodegenerative Diseases". Neuropharmacology 136: 449-58 
  2. Chen M.-W., Zhu H., et al. (Mai 2020). "PKC and Ras are Involved in M1 Muscarinic Receptor-Mediated Modulation of AMPA Receptor GluA1 Subunit". Cellular and molecular neurobiology 40 (4): 547-54 
  3. Lyon A. M., Taylor V. G., Tesmer J. J. G. (Ian 2014). "Strike a pose: Gαq complexes at the membrane". Trends in pharmacological sciences 35 (1): 23-30 
  4. Sánchez-Fernández G., Cabezudo S., et al. (Mai 2014). "Gαq signalling: the new and the old". Cellular signalling 26 (5): 833-48 
  5. Proctor G. B., Carpenter G. H. (2007). "Regulation of Salivary Gland Function by Autonomic Nerves". Autonomic neuroscience: basic & clinical 133 (1): 3-18 

Nexus interni

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