Aldolases (diligentius Fructoso-1,6-bis-phosphati-aldolasis) (Numeri EC: 4.1.2.13) sunt familia trium enzymorum: quae aldolasis A enim, aldolasis B, et aldolasis C dicuntur.

Fructoso-1,6-bis-phosphati aldolasis humani octamerum.

Enzymum aldolasis est pars glycolysis quo reactionem quarta, a fructoso-bisphosphato ad glyceraldehydro-3-phosphatum et dihydroxyacetonophosphatum perficit:

D-fructoso-1,6-bis-phosphatum di-hydroxy-acetono phosphatum + D-glyceraldehydo-3-phosphatum

In cellulis aldolasis etiam cum H+-ATPasi (ATP + H
2
O
+ H+
introrsum ADP + phosphate + H+
extrorsum) interagit[1].

AldolumRecensere

 
Aldolum.

Aldolum in chemia est verbum amalgamatum ex gregibus chemicis aldehydi et alcoholum compositum est.

AldolasesRecensere

Tres isoformae notae sunt, A (muscularis), B (hepatica), C (cerebralis).

Aldolasis ARecensere

Aldolasis A in musculis reperiuntur. In hominibus genum nomine ALDOA chromosomate 16 (16p11.2) locatum est.

Aldolasis BRecensere

Aldolasis B in iecore reperiuntur. In hominibus genum nomine ALDOB chromosomate 9 (9q31.1) locatum est. Gradus eius activus ab statu nutritivo pendet: parvus in fame, magnus post cibum[2].

Aldolasis CRecensere

Aldolasis C in cerebro (hippocampo) reperiuntur. In hominibus genum nomine ALDOC chromosomate 17 (17q11.2) locatum est.

PinacothecaRecensere

NotaeRecensere

  1. Lu M., Holliday L. S., Zhang L., Dunn W. A. Jr., Gluck S. L. (2001). "Interaction between aldolase and vacuolar H+-ATPase: evidence for direct coupling of glycolysis to the ATP-hydrolyzing proton pump". The journal of biological chemistry 276 (32): 30407-13 
  2. Munnich A., Besmond C., Darquy S., Reach G., Vaulont S., Dreyfus J. C., Kahn A. (1985). "Dietary and hormonal regulation of aldolase B gene expression". The journal clinical investigation 75 (3): 1045-52