L-Aminoacidorum aromaticorum decarboxylasis

L-Aminoacidorum aromaticorum decarboxylasis (abbreviaturae AAAD et AADC) sive DOPA decarboxylasis (DDC) (Numerus EC: 4.1.1.28) est enzymum, quod quasdam reactiones biochemicas celebrat, imprimis duos neurotransmissores, dopaminum et serotoninum, insignes generat. De functione AADC biochemica est lyasium et effectus suus est decarboxylatio (eripere gregem carboxylici R–COOH, dein liberare carbonii dioxidum CO₂. Nomen geni DDC scribitur et genum in hominibus chromosomate septimo invenitur^[1].

In cerebro humano AADC imprimis in nucleis raphes mesencephali demonstrari potest, atque in ponte cerebri (parte anteriore) et in medulla oblongata^[2].

In pharmacologia inhibitio AADC momentum magnitudinis effectuum prolongatorum praecursoris L-dihydroxy-phenylalanini (L-DOPA) neurotransmissorium, quod necesse tractationis morbi Parkinson est. In oncologia AADC cursum adenocarcinomatum stomachi indicare potest^[3].

De functione

Enzymum ADCC duos neurotransmissores, dopaminum et serotoninum generat^[4].

Genetica

Nomen geni DDC (DOPA decarboxylasis) notum est. Locus eius geneticus est in hominibus chromosomate 7 (7p12.2-12.1). Coordinata genetica sunt 7:50,458,435-50,565,459.

Nexus interni

Notae

↑ Scherer LJ, McPherson JD, Wasmuth JJ, Marsh JL (1992). "Human dopa decarboxylase: localization to human chromosome 7p11 and characterization of hepatic cDNAs". Genomics 13 (2): 469-71
↑ Kitahama K, Ikemoto K, Jouvet A, Araneda S, Nagatsu I, Raynaud B, Nishimura A, Nishi K, Niwa S (2009). "Aromatic L-amino acid decarboxylase-immunoreactive structures in human midbrain, pons, and medulla". J Chem Neuroanat 38 (2): 130-40
↑ Florou D, Papadopoulos IN, Fragoulis EG, Scorilas A (2013). "L-Dopa decarboxylase (DDC) constitutes an emerging biomarker in predicting patients' survival with stomach adenocarcinomas". J Cancer Res Clin Oncol 139 (2): 297-306
↑ Christenson JG, Dairman W, Udenfriend S (1972). "On the identity of DOPA decarboxylase and 5-hydroxytryptophan decarboxylase (immunological titration-aromatic L-amino acid decarboxylase-serotonin-dopamine-norepinephrine)". Proc Natl Acad Sci U S A 69 (2): 343-7

Nexus externi

[1] Scherer LJ, McPherson JD, Wasmuth JJ, Marsh JL (1992). "Human dopa decarboxylase: localization to human chromosome 7p11 and characterization of hepatic cDNAs". Genomics 13 (2): 469-71

[2] Kitahama K, Ikemoto K, Jouvet A, Araneda S, Nagatsu I, Raynaud B, Nishimura A, Nishi K, Niwa S (2009). "Aromatic L-amino acid decarboxylase-immunoreactive structures in human midbrain, pons, and medulla". J Chem Neuroanat 38 (2): 130-40

[3] Florou D, Papadopoulos IN, Fragoulis EG, Scorilas A (2013). "L-Dopa decarboxylase (DDC) constitutes an emerging biomarker in predicting patients' survival with stomach adenocarcinomas". J Cancer Res Clin Oncol 139 (2): 297-306

[4] Christenson JG, Dairman W, Udenfriend S (1972). "On the identity of DOPA decarboxylase and 5-hydroxytryptophan decarboxylase (immunological titration-aromatic L-amino acid decarboxylase-serotonin-dopamine-norepinephrine)". Proc Natl Acad Sci U S A 69 (2): 343-7

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