Carcinosarcoma

Carcinosarcoma est eodem tempore praesentia et carcinomatis (epithelio derivati) et sarcomatis (mesenchymate derivati). Carcinosarcomata tumores rari sunt. In compluribus organibus ut cute^[1], glandulis salivariis^[2], pulmonibus^[3], oesophago^[4], pancreate^[5], colo^[6], utero^[7], ovariis^[8] nonnumquam inveniri queant.

Cave: notitiae huius paginae nec praescriptiones nec consilia medica sunt.

Carcinosarcoma
Cognitores
Disciplina medica	Oncologia
Rationes clinicae

Endometrii carcinosarcoma cum duabus partibus, carcinomatosa et sarcomatosa - In imagine linea zonae transitionalis oblique currit.

Pathologia

Examinatio histopathologica eodem tempore textus neoplasticos et cellulis epithelialibus (carcinoma) et mesenchymalibus (sarcoma) derivatos ostendit.

Carcinosarcomatum origo incerta restat, itaque adhuc hypotheses quattuor dari solent:

Tumorum collisio — Tumores duo (carcinoma et sarcoma) in neoplasma singulare coalescent'.
Tumorum compositio — Sarcoma reactio praesentiae carcinomatis est.
Tumorum combinatio — A cellula neoplasmatica progenitore singulari cellulae et carcinomatosae et sarcomatosae oriuntur.
Tumoris conversio — Intra carcinoma cellulae carcinomatosae transformationem metaplasticam passae sunt^[9].

Mutationes geneticae ad carcinosarcomata formanda putatur, per exemplum in uteri carcinosarcomatibus mutationes proteini p53 nexus etiam ad proteinum FBXW7 et enzymum phosphoinositidi 3 kinasem indicaverunt^[10].

Notae

↑ Kwak H.-B., Park J., et al. (Dec 2018). "Cutaneous Carcinosarcoma: a Clinicopathologic and Immunohistochemical Analysis of 11 Korean Cases". Journal of Korean medical sciences 34 (1): e5
↑ Gupta A., Koochakzadeh S., et al. (Mai 2020). "Salivary Carcinosarcoma: An Extremely Rare and Highly Aggressive Malignancy". Laryngoscope 130 (5): E335-9
↑ Diaconită G. (Dec 1975). "Bronchopulmonary carcinosarcoma". Thorax 30 (6): 682-6
↑ Lichter I., Smith E. R., Gwynne J. F. (Nov 1968). "Carcinosarcoma of the oesophagus". Thorax 23 (6): 663-9
↑ Li J., Wei T., et al. (Nov 2020). "Carcinosarcoma of the pancreas: comprehensive clinicopathological and molecular characterization". HPB 22 (11): 1590-5
↑ Nakao A., Sakagami K., et al. (Apr 1998). "Carcinosarcoma of the colon: report of a case and review of the literatur". Journal of gastroenterology 33 (2): 276-9
↑ Arend R., Doneza J. A., Wright J. D. (Sep 2011). "Uterine carcinosarcoma". Current opinion in oncology 23 (5): 531-5
↑ Cantrell L. A., Van Le L. (Oct 2009). "Carcinosarcoma of the ovary a review". Obstetrical & gynecological survey 64 (10): 673-80
↑ Raspollini M. R., Taddei G. L., et al. (Mar-Apr 2005). "Differential diagnosis between uterine carcinosarcoma versus carcinoma with sarcomatous metaplasia: an immunohistochemical and ultrastructural case study". Ultrastructural pathology 29 (2): 149-55
↑ Cuevas I. C., Sahoo S. S., et al. (Dec 2019). "Fbxw7 is a driver of uterine carcinosarcoma by promoting epithelial-mesenchymal transition". Proceedings of the National Academy of Sciences of the United States of America 116 (51): 25880-90

Nexus externi

Pathologyoutlines.com de carcinosarcomatibus (Anglice)

stipula

Haec stipula ad medicinam spectat. Amplifica, si potes!

[1] Kwak H.-B., Park J., et al. (Dec 2018). "Cutaneous Carcinosarcoma: a Clinicopathologic and Immunohistochemical Analysis of 11 Korean Cases". Journal of Korean medical sciences 34 (1): e5

[2] Gupta A., Koochakzadeh S., et al. (Mai 2020). "Salivary Carcinosarcoma: An Extremely Rare and Highly Aggressive Malignancy". Laryngoscope 130 (5): E335-9

[3] Diaconită G. (Dec 1975). "Bronchopulmonary carcinosarcoma". Thorax 30 (6): 682-6

[4] Lichter I., Smith E. R., Gwynne J. F. (Nov 1968). "Carcinosarcoma of the oesophagus". Thorax 23 (6): 663-9

[5] Li J., Wei T., et al. (Nov 2020). "Carcinosarcoma of the pancreas: comprehensive clinicopathological and molecular characterization". HPB 22 (11): 1590-5

[6] Nakao A., Sakagami K., et al. (Apr 1998). "Carcinosarcoma of the colon: report of a case and review of the literatur". Journal of gastroenterology 33 (2): 276-9

[7] Arend R., Doneza J. A., Wright J. D. (Sep 2011). "Uterine carcinosarcoma". Current opinion in oncology 23 (5): 531-5

[8] Cantrell L. A., Van Le L. (Oct 2009). "Carcinosarcoma of the ovary a review". Obstetrical & gynecological survey 64 (10): 673-80

[9] Raspollini M. R., Taddei G. L., et al. (Mar-Apr 2005). "Differential diagnosis between uterine carcinosarcoma versus carcinoma with sarcomatous metaplasia: an immunohistochemical and ultrastructural case study". Ultrastructural pathology 29 (2): 149-55

[10] Cuevas I. C., Sahoo S. S., et al. (Dec 2019). "Fbxw7 is a driver of uterine carcinosarcoma by promoting epithelial-mesenchymal transition". Proceedings of the National Academy of Sciences of the United States of America 116 (51): 25880-90

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