Zuclopenthixolum
Zuclopenthixolum est medicamentum pharmaceuticum et antipsychoticum ad schizophreniam tractandam[1]. Substantia thioxanthenum antagonistaque receptoria dopamini D1 atque D2, adrenergica α1 et serotonini 5-HT2 obsidet. Frequenter effectus adversarii ut os siccum, ademptio conscientiae, inquies motuum sive nimium sive tarditas eorum observari possunt.
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| Cognitores | |
|---|---|
| ChemSpider | 4470984 |
| PubChem | 5311507 |
| DrugBank | DB01624 |
| Natura chemica | |
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| Formula chemica | C22H25ClN2OS |
| Massa molaris | 400.965 g/mol |
| Natura pharmacologica | |
| Codex ATC | N05AF05 (WHO) |
| Semivita biologica | 20 horae (per os) 19 dies (i.m.) |
| Metabolismus | iecore (hepaticus): CYP2D6, CYP3A4 |
| Excretio | faecibus |
| Ad usum therapeuticum | |
| Applicatio | per os, i.m. |
Zuclopenthixolum est Clopenthixoli cis-isomerus.
Natura zuclopenthixoli
recensereNatura chemica
recensereZuclopenthixolum est cis-(Z)-2-(4-(3-(2-chloro-9H-thioxantheno-9-ilideno)-propylo)-piperazino-1-yl)-aethanolum. Massa molaris est 400.965 g/mol.
Natura pharmacologica
recenserePharmacocinetica
recensereSemivita biologica .[2] 20 horae est, at administratione intramusculari 19 dies. Putatur, ut in senectute concentratio substantiae in sanguine, functione CYP2D6 diminuta causa, aucta sit[3]. Excretio imprimis per faecibus (85%) fit.
Nexus interni
Notae
recensere- ↑ Bryan EJ, Purcell MA, Kumar A (2017). "Zuclopenthixol dihydrochloride for schizophrenia". Cochrane Database Syst Rev 11: CD005474
- ↑ IUPAC Goldbook.
- ↑ Tveito M., Løvsletten Smith R., et al. (Feb 2021). "Impact of age and CYP2D6 genotype on exposure of zuclopenthixol in patients using long-acting injectable versus oral formulation-an observational study including 2044 patients". European journal of clinical pharmacology 77 (2): 215-21