Flupentixolum
compositum chemicum
Flupentixolum est substantia antipsychotica, agonista dopamini partialis (D2 > D3), ad schizophreniam tractandam. Flupentixolo duo isomeri sunt: formae cis et trans. Medicamentum intervallum QT prolongatum contrahere potest.
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| Natura chemica | |
|---|---|
| Formula chemica | C 23H 25F 3N 2OS |
| Massa molaris | 434.5219 g/mol |
| PubChem | 5281881 |
| DrugBank | DB00875 |
| Natura pharmacologica | |
| Codex ATC | N05AF01 (WHO) |
| Tempus semivitae biologicum | 35 h |
| Metabolismus | hepaticus |
| Excretio | renibus (min.)[1] |
| Ad usum therapeuticum | |
| Applicatio | per os, i.m. |
| Dosis diurna definita (DDD) | 6 mg (p.o.) 4 mg (i.m.) |
Natura Flupentixoli
recensereNatura chemica
recensereStructura chemica cis,trans-4-[3-(2-trifluormethyl-9-thioxanthenyliden)propyl]-1-piperazino-aethanolum et massa molaris 434.5219 g/mol est.
Natura pharmacologica
recensereFlupentixolum est medicamentum cum virtutibus antipsychoticis. Praeterea antidepressivi effectus noti sunt[2]. Codex ATC est N05AF01 (WHO).
Pharmacodynamica
recensereFlupentixolum potissime receptoria dopamini D2, paulo minus receptoria D3 et H1 obsidet.
Usus Flupentixoli
recensereUsus medicus
recensereDosis diurna definita (DDD) est 6 mg per die et p.o., 4 mg i.m.[3]
Notae
recensere- ↑ Balant-Gorgia A. E., Balant L. (1987). "Antipsychotic drugs. Clinical pharmacokinetics of potential candidates for plasma concentration monitoring". Clinical pharmacokinetics 13 (2): 65-90
- ↑ Young J. P., Hughes W. C., Lader M. H. (1976). "A controlled comparison of flupenthixol and amitriptyline in depressed outpatients". British medical journal 1 (6018): 1116-8
- ↑ Systema classificationis Anatomicum Therapeuticum Chemicumque, cap. N05AF cum Flupentixoli referentia
Nexus externi
recensere- Situs interretialis fabricatoris Cariprazini (divulgationibus) (Anglice)