Biperidenum
compositum chemicum
Biperidenum est substantia anticholinergica antagonista receptoriorum muscarinergicorum M1 et M4. Adhibetur morbi Parkinsoniani et perturbationum motuum drogis causa.
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Cave: notitiae huius paginae nec praescriptiones nec consilia medica sunt. |
| Cognitores | |
|---|---|
| ChemSpider | 2289 |
| PubChem | 2381 |
| DrugBank | DB00810 |
| Natura chemica | |
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| Formula chemica | C 21H 29NO |
| Massa molaris | 311.469 g/mol |
| Natura pharmacologica | |
| Codex ATC | N04AA02 (WHO) |
| Semivita biologica | 18—24 h |
| Metabolismus | iecore (hepaticus): hydroxylatio |
| Excretio | renibus |
| Ad usum therapeuticum | |
| Applicatio | per os., i.m., i.v. |
Biperidenum in ordinis mundi sanitarii indicem exemplarem medicamentorum essentialium receptum est.
Natura pharmacologica biperideni
recenserePharmacodynamica
recensereBiperidenum substantia anticholinergica antagonista receptoriorum muscarinergicorum M1 et M4 est[1]. Effectus clinici 6-8 horas remanent.
Maxima hominis dosis diurnalis 16 mg valet. Antidotum physostigminum, parasympathomimeticum indirectum (inhibitione acetylcholini esterasis), est.
Pharmacocinetica
recensereSemivita biologica .[2] 18-24 h est. Excretio maiore in parte per renes est.
Usus medicus
recensere- Morbus Parkinsonianus
- Perturbationes motuum drogis (ut antipsychoticis) causa
- Hypersalivatio (sialorrhoea) consumptione clozapini[3], methadoni[4].
Notae
recensere- ↑ Palombo P., Engi S. A., et al. (Feb 2021). "Effects of biperiden (cholinergic muscarinic m1/m4 receptor antagonist) on ethanol conditioned place preference in mice". Neuroscience letters 745: 135551.
- ↑ http://goldbook.iupac.org/B00658.html
- ↑ Richardson C., Kelly D. L., Conley R. R. (Aug 2001). "Biperiden for excessive sweating from clozapine". American journal of psychiatry 158 (8): 1329-30.
- ↑ Caflisch C., Figner B., Eich D. (Feb 2003). "Biperiden for excessive sweating from methadone". American journal of psychiatry 160 (2): 386-7.
Nexus interni
Nexus externi
recensere- drugs.com cum monographia biperideni (Anglice)