Significans iter PI3K/AKT/mTOR

Significans iter PI₃K/AKT/mTOR est signum transductus intra cellulam quocum programmata cellularia mutari possunt^[1]. Hoc iter momentum quoque cancri, longevitatis, status quiescendi cellulae. Nomen itineris de enzymis phosphoinositidi 3-kinasis (PI₃K) et nominis abbreviaturae enzymi proteini kinasis B, AKT, et mTOR (abbreviatura Anglica "scopi Rapamycini in mammaliis") oritur.

Significans iter PI₃K/AKT/mTOR. Supra *PI₃K* invenitur, et paulo infra *proteini kinasis B* abbreviatura Akt/PKB ostendit. Significanti itineri duo complexa mTOR includuntur, *mTORC1* et *mTORC2*.
Iter cum activatione PI₃ coepit, stimuli sunt insulinum (indirecte), factores incrementi (*growth factors*) (ut in cancro, velut enzymum TELO2 (longitudinis telomerium).

Physiologia

Phosphoinositidi 3-kinasis

Phosphoinositidi 3-kinasis (PI₃K) est familia enzymorum cum classibus quattuor (I-IV). Functio itineris est signum transductor, non dumtaxat in hoc, sed etiam in itinere insulini.

mTOR

mTOR est membrum complexorum enzymorum duorum mTORC1 et mTORC2. Responsum incrementis functionum cellulae mTORC1 translationem proteinorum incidit. mTORC2 cytosceletus gubernat.

Notae

↑ Suprynowicz FA, Kamonjoh CM, Krawczyk E, Agarwal S, Wellstein A, Agboke FA, Choudhury S, Liu X, Schlegel R (2017). "Conditional cell reprogramming involves non-canonical β-catenin activation and mTOR-mediated inactivation of Akt". PloS One 12 (7): e0180897

Nexus interni

biochemia

Haec stipula ad biochemiam spectat. Amplifica, si potes!

stipula

Haec stipula ad biologiam spectat. Amplifica, si potes!

[1] Suprynowicz FA, Kamonjoh CM, Krawczyk E, Agarwal S, Wellstein A, Agboke FA, Choudhury S, Liu X, Schlegel R (2017). "Conditional cell reprogramming involves non-canonical β-catenin activation and mTOR-mediated inactivation of Akt". PloS One 12 (7): e0180897

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