Proteostasis

Proteostasis (portmanteau: proteinum + homeostasis) est notio quod affirmat vias biologicas certantes integrasque intra cellulas biogenesim, flexuram, mutationem, et degradationem proteinorum intra extraque cellulam praesentes temperare. Notio proteostasis conservatae est res maximi momenti in studio causarum morborum cum nimis malae plicationis proteinorum et degradationis consociatorum ac degradationem quae ad phenotypos facultatum amissarum efficit, ac morbis degenerativis cum aggregatione consociatis.

Responsa signorum nisus in proteostasi adumbrata.

Nexus interni

• Enantiostasis
• Homeostasis

Bibliographia

• Balch, W. E., R. I. Morimoto, A. Dillin, et J. W. Kelly. 2008. Adapting proteostasis for disease intervention. Science 319:916–919. doi:10.1126/science.1141448. PMID 18276881.
• Cohen, E., J. F. Paulsson, P. Blinder, T. Burstyn-Cohen, D. Du, G. Estepa, A. Adame, H. M. Pham, M. Holzenberger, J. W. Kelly, E. Masliah, et A. Dillin. 2009. Reduced IGF-1 signaling delays age-associated proteotoxicity in mice. Cell 139:1157–69. doi:10.1016/j.cell.2009.11.014. PMID 20005808.
• Mu, T.-W., D. S. T. Ong, Y.-J. Wang, W. E. Balch, J. R. Yates, L. Segatori, et J. W. Kelly. 2008. Chemical and Biological Approaches Synergize to Ameliorate Protein-Folding Diseases. Cell 134:769–781. doi:10.1016/j.cell.2008.06.037. PMID 18775310.
• Powers, E. T., R. I. Morimoto, A. Dillin, J. W. Kelly, et W. E. Balch. 2009. Biological and Chemical Approaches to Diseases of Proteostasis Deficiency. Annual Review of Biochemistry 78:959–991. doi:10.1146/annurev.biochem.052308.114844. PMID 19298183.

Nexus externi

• "Proteostasis: where do you work on the network?" Enzo Life Sciences, enzolifesciences.com.
• Situs proprius. Proteostasis Therapeutics, proteostasis.com.