Folliculos stimulans hormon

Folliculos stimulans hormon, abbreviatura FSH, est hormon e duabus catenis, alpha (FSHA, OMIM: 118850) et beta (FSHB, OMIM: 136530), compositum. FSH de cellulis gonadotropicis lobi anterioris hypophysis secernitur. Et in viribus et in mulieribus hormonti FSH munera diversa sunt.

Physiologia FSH

Secretio

Secretio hormontis folliculos stimulantis praecipue ab hypothalamo per hormon liberationis gonadotropinorum (GnRH), quod est decapeptidum, moderatur; secretio ipsa a cellulis gonadotropicis, quae in lobo anteriori hypophysis sitae sunt, fit^[1]. Intra hypophysem, complexus proteinorum et activini (biosynthesis FSH ↑) et inhibini (biosynthesis FSH ↓), velut follistatinum in edita moderandis agunt^[2]. Activinum genum promotorem Fshb subunitatis beta lectum incitat. Subunitas alpha, ut LH, genum alphaGSU requirit.

Cyclus menstrualis mulierum

Secretio hormontis FSH secundum cyclum muliebrem

Cyclo menstruali ineunte FSH folliculos immaturos in ovariis stimulat. In medio cyclo maior effusio ipsius ovulationem incitat^[3].

Spermatogenesis in viris

FSH spermatozoa in testibus virorum stimulat^[4].

Notae

↑ Sharma T. P., Nett T. M., Karsch F. J., Phillips D. J., Lee J. S., Herkimer C., Padmanabhan V. (2012). "Neuroendocrine control of FSH secretion: IV. Hypothalamic control of pituitary FSH-regulatory proteins and their relationship to changes in FSH synthesis and secretion". Biology of reproduction 86 (6): 171 doi:10.1095/biolreprod.111.098442
↑ Bilezikjian L. M., Justice N. J., Blackler A. N., Wiater E., Vale W. W. (Aug 2021). "Cell-type specific modulation of pituitary cells by activin, inhibin and follistatin". Molecular and cellular endocrinology 359 (1-2): 43-52 doi:10.1016/j.mce.2012.01.025
↑ Messinis I. E., Messini C. I., Dafopoulos K. (2014). "Novel aspects of the endocrinology of the menstrual cycle". Reproductive biomedicine online 28 (6): 714-22
↑ Huhtaniemi I. (2015). "A short evolutionary history of FSH-stimulated spermatogenesis". Hormones (Athens, Greece) 14 (4): 468-78

Nexus interni

Nexus externi

Laboratorium et FSH. (Anglice)

stipula

Haec stipula ad biologiam spectat. Amplifica, si potes!

[1] Sharma T. P., Nett T. M., Karsch F. J., Phillips D. J., Lee J. S., Herkimer C., Padmanabhan V. (2012). "Neuroendocrine control of FSH secretion: IV. Hypothalamic control of pituitary FSH-regulatory proteins and their relationship to changes in FSH synthesis and secretion". Biology of reproduction 86 (6): 171 doi:10.1095/biolreprod.111.098442

[2] Bilezikjian L. M., Justice N. J., Blackler A. N., Wiater E., Vale W. W. (Aug 2021). "Cell-type specific modulation of pituitary cells by activin, inhibin and follistatin". Molecular and cellular endocrinology 359 (1-2): 43-52 doi:10.1016/j.mce.2012.01.025

[3] Messinis I. E., Messini C. I., Dafopoulos K. (2014). "Novel aspects of the endocrinology of the menstrual cycle". Reproductive biomedicine online 28 (6): 714-22

[4] Huhtaniemi I. (2015). "A short evolutionary history of FSH-stimulated spermatogenesis". Hormones (Athens, Greece) 14 (4): 468-78

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