Zona subparaventricularis
Zona subparaventricularis (ZSP) est intra cerebrum regio hypothalami, cum numeris et circadianis et ultradianis coniuncta. Recipit indita a nucleo suprachiasmatico, neutrotransmissor sunt GABA et polypeptidum intestinale vasoactivum.
Videtur, ut zona subparaventricularis numerum ultradianum intervalli inter horas dimidium et quattuor generet.
Forsitan functio mala ZSP iras sub vesperum morbo neurodegenerativo affectorum hominum in parte explicare potest[1].
Anatomia microscopica
recensereInvenitur zona subparaventricularis non procul ab ventriculi tertii recessu optico, super nucleum suprachiasmaticum et nucleo paraventriculari anterius. Structura ZSP cytoarchitectura homogena fere apparet.
Physiologia
recensereUna cum nucleo paraventricularis zona subparaventricularis numerum ultradianum cum intervallis inter 0.5 — 4 horas generae videtur[2]. Tetrodotoxinum, quod natrii canales obsidet, numerum ultradianum inhibet. Rhythmus ultradianus per inhibitores receptoriorum glutamati terminatur, at inhibitores receptoriorum GABA-A frequentiam augent. Ita putatur, ut systema GABAergicum pars maior numerum ultradianum generandi sit.
Indita
recensereRecipit ZSP indita superiora ex nucleo suprachiasmatico. Synapses fibrarum nuclei suprachiasmatici neurotransmissores et GABA et polypeptidum intestinale vasoactivum continent[3]. Putatur, ut receptoria praesynaptica, forsitan receptoriis VPAC2, liberationem GABA facilius faciant.
Intra zonam divisiones distingui possunt:
- subdivisio dorsalis — numerus temperaturae corporis
- subdivisio ventralis — somni et motuum[4]
- subdivisio medialis — indita imprimis ab nucleo suprachiasmatico dorsomediali
- subdivisio lateralis — indita imprimis ab nucleo suprachiasmatico ventrolaterali velut a tractu retinohypothalamico[5]
Edita
recensereEdita in regio septalem, thalamum, hypothalamum, truncum cerebri mittuntur[6].
Notae
recensere- ↑ Todd W. D., Fenselau H., et al. (Mai 2018). "A hypothalamic circuit for the circadian control of aggression". Nature neuroscience 21 (5): 717-24
- ↑ Wu Y.-E., Enoki R., et al. (Oct 2018). "Ultradian calcium rhythms in the paraventricular nucleus and subparaventricular zone in the hypothalamus". Proceedings of the National Academy of Sciences of the United States of America 115 (40): E9469-78
- ↑ Hermes M. L. H. J., Kolaj M., et al. (Sep 2009). "Effects of VPAC2 receptor activation on membrane excitability and GABAergic transmission in subparaventricular zone neurons targeted by suprachiasmatic nucleus". Journal of neurophysiology 102 (3): 1834-42
- ↑ Lu J., Zhang Y. H., et al. (Iul 2001). "Contrasting effects of ibotenate lesions of the paraventricular nucleus and subparaventricular zone on sleep-wake cycle and temperature regulation". The journal of neuroscience 21 (13): 4864-74
- ↑ Leak R. K., Moore R. Y. (Mai 2001). "Topographic organization of suprachiasmatic nucleus projection neurons". The journal of comparative neurology 433 (3): 312-34
- ↑ Vujovic N., Gooley J. J., et al. (Dec 2015). "Projections from the subparaventricular zone define four channels of output from the circadian timing system". The journal of comparative neurology 523 (18): 2714-37
Nexus interni
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