Emendatio ex 10:54, 15 Iunii 2017 recensere Andreas Raether (disputatio \| conlationes) Magistratus 17 229 edits m &cat neurotransmissores ← Differentia superior		Emendatio ex 22:16, 4 Octobris 2017 recensere abrogare Bis-Taurinus (disputatio \| conlationes) 4 679 edits Complures errores minores correxi. Differentia proxima →
Linea 1: [[Fasciculus:Serotonin-skeletal.png\|200px\|thumb\|Forma [[molecula]]e '''serotonini''']] [[Fasciculus:5-HT Neuron.svg\|thumb\|'''Serotonini''' biosynthesis, imminutio et effectus moleculares in rima synaptica]] '''Serotoninum''' seu '''5-hydroxytryptaminum''' ('''5-HT''') sive '''enteraminum''' est [[hormon]], accurate [[indolaminum]], quod cum [[dopaminum\|dopamino]], [[noradrenalinum\|noradrenalino]] et [[adrenalinum\|adrenalino]] ad complexum [[monoaminum\|monoaminorum]] pertinet. In corpore a multis membris ([[iecur\|iecore]], [[lien]]e, [[systema nervosum\|systemate nervoso centrali]]) effunditur. == Biochemia == [[Fasciculus:Serotonin biosynthesis.svg\|thumb\|[[Synthesis biologica]]. - '''Serotoninum''' ~~cum~~ex [[hydroxylatio\|hydroxylatione]] [[tryptophanum\|tryptophani]], tum [[decarboxylatio\|decarboxylatione]] [[5-hydroxytryptophanum\|5-hydroxytryptophani]] fit [[reactio chemica\|reactionibus chemicis]] ~~duobus~~duabus, ~~utrisque~~quibus ~~propium~~singula [[enzymum\|emzyma]] ~~attributum~~attributa ~~est~~sunt. [[Denominatio internationalis communis~~\|Denominationen internationalem communem~~]] (''INN'') 5,6,7,8-tetrahydrobiopterini [[sapropterinum]] ~~esse notetur~~est.]] === Synthesis biochemica === [[Synthesis biologica]] serotonini gradibus duobus accidit, primo [[hydroxylatio\|hydroxylatione]] [[tryptophanum\|tryptophani]] deinde [[decarboxylatio\|decarboxylatione]] [[5-hydroxytryptophanum\|5-hydroxytryptophanum]]. ==== Tryptophani hydroxylasis (tryptophanum) ==== [[Tryptophanum]], [[acidum aminicum]], est substantia initialis. In [[enzymum\|enzymi]] [[tryptophani hydroxylasis]]<ref>{{cite journal \|authors=Boularand S, Darmon MC, Ganem Y, Launay JM, Mallet J \|title=Complete coding sequence of human tryptophan hydroxylase \|journal=Nucleic Acids Res \|year1990 \|month=iul \|volume=18 \|pages=4257 \|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC331198/ }}</ref> praesentia tryptophano ~~gregem~~grex hydroxidi (-OH, [[oxygenium]] cum [[hydrogenium\|hydrogenio]]) additur. [[Enzymum]] [[tryptophani hydroxylasis]] ([[~~TPH1~~TPH 1]] et -solum in [[cerebrum\|cerebro]]- [[~~TPH2~~TPH 2]]) cum [[cofactor (biochemia)\|cofactore]] Fe<sup>++</sup> in communione cum [[sapropterinum\|sapropterino]] et [[oxygenium\|oxygenio]] (O<sub>2</sub>) aliud [[acidum aminicum]] chemicum, quod [[5-hydroxytryptophanum]] nominatur, format. ==== Decarboxylasis acidorum aminicorum aromaticorum (5-hydroxytryptophanum) ==== [[5-hydroxytryptophanum]] tunc [[decarboxylasis acidorum aminicorum aromaticorum\|decarboxylasi acidorum aminicorum aromaticorum]] [[carbonii dioxidum]] (CO<sub>2</sub>) reddit, ideo structura [[acidum aminicum\|acidi aminici]] sua perdit. Substantia ~~chemia~~chemica nova est 5-hydroxytryptaminum, sive serotoninum. [[cofactor (biochemia)\|Cofactor]] est vitaminum B<sub>6</sub> (''PLP'', [[pyridoxalum\|pyridoxali]] 5'-[[phosphatum]]). == Notae ==

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