Somatostatinum

Somatostatinum (SST) sive proventui hormonti inhibens hormon est hormon peptidum, quod systema endocrineum gubernat. In apparatu digestorio (cellulis somatotropicis) et cerebro (neuronis somatostatinergicis) liberatur. Etiam cellulae et inflammatoriae et immunitatis secernunt. Hormontis effectus per receptoria somatostatino propria, SSTR1-5, transmittuntur^[1].

Structura chemica hormontis somatostatini

Munera diversa descripta sunt:

Inhibitio proventus hormontis (GH)^[2]
Intra systema nervosum centrale inhibitio neurotransmissionis
Liberatione de pancreate exocrino gubernatio liberationis insulini et glucagoni^[3]
Reductio secretionis gastricae^[4]

In hominibus derivantur duae formae somatostatini ab proteino praecursore, prepraesomatostatino ex 116 aminoacidis composito, cum 14 aminoacidorum (somatosatinum 14) et 28 (somatostatinum 28)^[5].

Somatostatini receptoria

In hominibus receptoria proteino G copulata somatostatini quinque, SSTR 1, SSTR 2, SSTR 3, SSTR 4, SSTR 5, descripta sunt^[6].

Notae

↑ Patel Y. C. (Iul 1999). "Somatostatin and its receptor family". Frontiers in neuroendocrinology 20 (3): 157-98
↑ Brazeau P., Vale W., et al. (1973). "Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone". Science 179 (4068): 77-9
↑ Strowski M. Z., Blake A. D. (Mai 2008). "Function and expression of somatostatin receptors of the endocrine pancreas". Molecular and cellular endocrinology 286 (1-2): 169-79
↑ Piqueras L., Martínez V. (Dec 2004). "Role of somatostatin receptors on gastric acid secretion in wild-type and somatostatin receptor type 2 knockout mice". Naunyn-Schmiedeberg's archives of pharmacology 370 (6): 510-20
↑ Shen L. P., Pictet R. L., Rutter W. J. (Aug 1982). "Human somatostatin I: sequence of the cDNA". Proceedings of the National Academy of Sciences of the United States of America 79 (15): 4575-9
↑ Hoyer D., Bell G. I., et al. (Mar 1995). "Classification and nomenclature of somatostatin receptors". Trends in pharmacological sciences 16 (3): 86-8

Nexus interni

Hypophysis

Nexus externi

stipula

Haec stipula ad biologiam spectat. Amplifica, si potes!

[1] Patel Y. C. (Iul 1999). "Somatostatin and its receptor family". Frontiers in neuroendocrinology 20 (3): 157-98

[2] Brazeau P., Vale W., et al. (1973). "Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone". Science 179 (4068): 77-9

[3] Strowski M. Z., Blake A. D. (Mai 2008). "Function and expression of somatostatin receptors of the endocrine pancreas". Molecular and cellular endocrinology 286 (1-2): 169-79

[4] Piqueras L., Martínez V. (Dec 2004). "Role of somatostatin receptors on gastric acid secretion in wild-type and somatostatin receptor type 2 knockout mice". Naunyn-Schmiedeberg's archives of pharmacology 370 (6): 510-20

[5] Shen L. P., Pictet R. L., Rutter W. J. (Aug 1982). "Human somatostatin I: sequence of the cDNA". Proceedings of the National Academy of Sciences of the United States of America 79 (15): 4575-9

[6] Hoyer D., Bell G. I., et al. (Mar 1995). "Classification and nomenclature of somatostatin receptors". Trends in pharmacological sciences 16 (3): 86-8

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