Optogenetica

Optogenetica (de verbis graecis ὀπτικός, visum attingens, et γενεά genesis) est in neuroscientia technologia biologica ad genetice cellulas, neuronos imprimis, modificatas gubernandas expressu ad lucem accipiendam canales ionticos, ut et cellularum vivarum et neuronorum activorum reactiones examinet. Igitur in neuronis optogenetica est neuromodulatio lucis ope.

Nematodum Caenorhabditis elegans ad lucem accipiendam canalem ionticum Mac exprimens - Lux semper corporis longitudinem auget.^[1]

Optogenetica, annis 2002 et 2003 inventa, methodos opticae et geneticae conducit.^[2]

Claves optogenetici ("actuatores") sunt canales ut rhodopsinum, halorhodopsinum, archaerhodopsinum, sed ad effectus imaginesve captandos receptoria optogenetica ("sensores") calcii (GCaMP - calcii indicator), vesicularum synapticarum liberationis (synapto-pHluorinum), neurotransmissoris (GluSnFRs), tensionis electricae membranarum (Arc Lightning, ASAP1) serviunt.

Notae

↑ Husson, S. J.; Liewald, J. F.; Schultheis, C.; Stirman, J. N.; Lu, H.; Gottschalk, A. (2012). "Microbial Light-Activatable Proton Pumps as Neuronal Inhibitors to Functionally Dissect Neuronal Networks in C. Elegans". In Samuel, Aravinthan. PLoS ONE 7 (7): e40937. doi:10.1371/journal.pone.0040937. PMC 3397962. PMID 22815873
↑ Deisseroth, K.; Feng, G.; Majewska, A. K.; Miesenbock, G.; Ting, A.; Schnitzer, M. J. (2006). "Next-Generation Optical Technologies for Illuminating Genetically Targeted Brain Circuits". Journal of Neuroscience 26 (41): 10380–6

Nexus externi

Laboratorium K Deisseroth de optogenetica. (Anglice)

stipula

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stipula

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[1] Husson, S. J.; Liewald, J. F.; Schultheis, C.; Stirman, J. N.; Lu, H.; Gottschalk, A. (2012). "Microbial Light-Activatable Proton Pumps as Neuronal Inhibitors to Functionally Dissect Neuronal Networks in C. Elegans". In Samuel, Aravinthan. PLoS ONE 7 (7): e40937. doi:10.1371/journal.pone.0040937. PMC 3397962. PMID 22815873

[Deisseroth_2006-2] Deisseroth, K.; Feng, G.; Majewska, A. K.; Miesenbock, G.; Ting, A.; Schnitzer, M. J. (2006). "Next-Generation Optical Technologies for Illuminating Genetically Targeted Brain Circuits". Journal of Neuroscience 26 (41): 10380–6

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