CYP2B6

Cytochroma P450 CYP2B6 (-atis, n.) (Numerus EC: 1.14.14.1) est enzymum et haemoproteinum et pars gregis Cytochroma P450 ideo in metabolismo medicamenti chemotherapiae, ut cyclophosphamidi sive ifosfamidi, interest. Circiter centesimae quinque reactionum catabolicarum medicamentorum cum cytochromate CYP2B6 patent^[1]. Variationes multae geneticae descriptae sunt.

Genetica

Phaenotypicae variantia

Locus geni geneticus CYP2B6 in chromosomate 19 (19q13.2) situs est^[2]. Polymorphismus geneticus cum plus quam centum variationibus magnum momentum habet^[1]

Pharmaca ad CYP2B6 relata

Substrati	Inhibitores^[5]	Inductores^[6]
Pharmaca relata ad CYP2B6^[3]^[4].
Acidum valproicum Bupropionum Cyclophosphamidum Efavirenzum Ifosfamidum Ketaminum^[7] Methadonum^[8] Methoxetaminum Nevirapinum Pethidinum Propofolum Selegelinum Sertralinum Sorafenibum Tamoxifenum	Aethinyloestradiolum Chlorpyrifosum Clopidogrelum Clotrimazolum Curcuminum Fluoxetinum Fluvoxaminum Itraconazolum Ketoconazolum Memantinum Orphenadrinum (forte) Paroxetinum Raloxifenum Sertralinum Thiotepa Ticlopidinum	Carbamazepinum Phenobarbitalum Phenytoinum Rifampicinum Efavirenzum

Nexus interni

Notae

↑ ^1.0 ^1.1 Turpeinen M, Zanger UM (2012). "Cytochrome P450 2B6: function, genetics, and clinical relevance". Drug Metabol Drug Interact 27 (4): 185-97
↑ "Entrez geni: cytochromum P450 CYP2B6"
↑ Cozza KL, Armstrong SC (2001). The Cytochrome P450 System. Drug Interaction Principles for Medical Practice. Washington, DC: American Psychiatric Publishing
↑ Preskorn SH (1996). Clinical Pharmacology of Selective Serotonin Reuptake Inhibitors. 1st ed.: Professional Communications, Inc.
↑ Inhibitor cum subtratorum effectibus fortioribus
↑ Inductor cum subtratorum effectibus minoribus
↑ Andrade C (2017). "Ketamine for Depression, 5: Potential Pharmacokinetic and Pharmacodynamic Drug Interactions". J Clin Psychiatry 78 (7): e858-61
↑ Kharasch ED, Stubbert K (2013). "Role of cytochrome P4502B6 in methadone metabolism and clearance". J Clin Pharmacol 53 (3): 305-13

Nexus externi

Descriptio cytochromatis CYP2B6.

[TURPEINEN-1] 1.0 ^1.1 Turpeinen M, Zanger UM (2012). "Cytochrome P450 2B6: function, genetics, and clinical relevance". Drug Metabol Drug Interact 27 (4): 185-97

[entrez-2] "Entrez geni: cytochromum P450 CYP2B6"

[3] Cozza KL, Armstrong SC (2001). The Cytochrome P450 System. Drug Interaction Principles for Medical Practice. Washington, DC: American Psychiatric Publishing

[4] Preskorn SH (1996). Clinical Pharmacology of Selective Serotonin Reuptake Inhibitors. 1st ed.: Professional Communications, Inc.

[5] Inhibitor cum subtratorum effectibus fortioribus

[6] Inductor cum subtratorum effectibus minoribus

[7] Andrade C (2017). "Ketamine for Depression, 5: Potential Pharmacokinetic and Pharmacodynamic Drug Interactions". J Clin Psychiatry 78 (7): e858-61

[8] Kharasch ED, Stubbert K (2013). "Role of cytochrome P4502B6 in methadone metabolism and clearance". J Clin Pharmacol 53 (3): 305-13

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