Quantum redactiones paginae "Proteinum praecursor amyloidi" differant
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Incrementum [[glutamatum|glutamati]] extracellularis influxum [[calium|calcii]] extracellularis (Ca<sup>2+</sup>) in cellulam incitat, quod damnum neurotoxicum perficere potest. Liberatum sAPP alpha sane transgressionem Ca<sup>2+</sup> hanc in cellulam supprimit<ref>{{cite journal |authors=Furukawa K., Mattson M. P. |title=Secreted amyloid precursor protein alpha selectively suppresses N-methyl-D-aspartate currents in hippocampal neurons: involvement of cyclic GMP |journal=Neuroscience |year=1998 |month=Mar |volume=83 |issue=2 |pages=429-38 |url=https://www.ncbi.nlm.nih.gov/pubmed/9460751}}</ref>. Per [[cyclicum guanosinum monophosphatum]] (cGMP) [[receptorium NMDA|receptoria NMDA]] ([[neurotransmissor]]is glutamati excitantis) pariter inhibentur ("neuroprotectio").
Praeterea proteino praecursori munera equilibrii ferri (egressionis Fe<sup>2+</sup>) habet, pariter ut [[enzymum]] [[caeruloplasminum]] in cellulis extra neurones (quibus non invenitur)<ref>{{cite journal |authors=Wong B. X., Tsatsanis A., Lim L. Q., Adlard P. A., Bush A. I., Duce J. A. |title=β-Amyloid precursor protein does not possess ferroxidase activity but does stabilize the cell surface ferrous iron exporter ferroportin |journal=PloS one |year=2014 |month=Dec |volume=9 |issue=12 |pages=e114174 |url=https://www.ncbi.nlm.nih.gov/pubmed/25464026/}}</ref>. Incrementum proteini praecursoris in neuroblastomate multitudinem ferri intra cellulam diminuit<ref>{{cite journal |authors=Wan L., Nie G., Zhang J., Zhao B. |title=Overexpression of human wild-type amyloid-β protein precursor decreases the iron content and increases the oxidative stress of neuroblastoma SH-SY5Y cells |journal=Journal of Alzheimer's disease |year=2012 |volume=30 |issue=3 |pages=523-30 |url=https://www.ncbi.nlm.nih.gov/pubmed/22451308/}}</ref>.
== Pathophysiologia et neuropathologia ==
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