Quantum redactiones paginae "Inflammasoma" differant

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[[Fasciculus:Inflammasome vector.svg|thumb|Structura inflammasomatis NLRP3.]]
'''Inflammasoma''' {{victio|soma|atis|n}} est complexus [[proteinum|proteinorum]] [[oligomerus (chemia)| oligomerusoligomerorum]] [[inflammatio|responsa inflammatoria responsa]]<ref name="TSCHOPP02">{{cite journal |authors=Martinon F., Burns K., Tschopp J. |title=The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta |journal=Mol Cell |year=2002 |volume=10 |issue=2 |pages=417-26 |url=https://www.ncbi.nlm.nih.gov/pubmed/12191486}}.</ref> per varios ''adaptores''<ref>{{cite journal |authors=Mariathasan S., Newton K., Monack D. M., Vucic D., French D. M., Lee W. P., Roose-Girma M., Erickson S., Dixit V. M. |title=Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf |journal=Nature |year=2004 |volume=430 |issue=6996 |pages=213-8 |url=https://www.ncbi.nlm.nih.gov/pubmed/15190255}}.</ref> excitatuexcitatus. Adaptoribus incitatum his inflammasoma [[enzymum]] [[caspasis 1|caspasem 1]]<ref>seu ''interleukini 1 beta convertasis''</ref> se immutare impellit ita, ut praecursor [[interleukinum 1 beta|interleukini 1 beta]] [[macrophagocytis]] liberatus in formam activam interleukinumi 1 activi (IL-1β) et [[febris|febrem]] generantis convertatur ideoque cataracta inflammationis biochemica continuetur.
 
''Inflammasomata complexus'', qui in [[textus myeloideus|textu myeloideo]] locati sunt ex enzymis caspasi 1 ac ''[[PYCARD]]'' et receptorio ''[[NALP]]'' et nonnumquam enzymo [[caspasis 5|caspasi 5]] compositi sunt. Variae formae rececptoriorum ''NALP'' complexu ligatae notae sunt.
 
=== Contextus ===
Sub [[inflammatio]]nem ''[[systema immunitatis]] innatum'' machinationem defensionis contestari oportet. Post stimulationem inflammasomate primum liberatio ex cellula cytokinorum conceditur, deinde extra cellulam [[pyroptosis]] (mors cellularum programmata) fit<ref>{{cite journal |authors=Fink S. L., Cookson B. T. |title=Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages |journal=Cell Microbiol |year=2006 |volume=8 |issue=11 |pages=1812-25 |url=https://www.ncbi.nlm.nih.gov/pubmed/16824040}}.</ref>.
 
=== Structura ===
Inflammasomata sunt complexus ex diversis proteinis compositi, ita ex [[enzymum|enzymis]] [[caspasis 1|caspasi 1]] ac ''[[PYCARD]]'' et receptorio ''[[NALP]]'' et nonnumquam enzymo [[caspasis 5|caspasi 5]]. Variae formae rececptoriorum ''NALP'' complexu ligatae notae sunt, quo inflammasomata ''NLRP1'' et ''NLRP3''<ref>{{cite journal |authors=Lebeaupin C., Proics E., de Bieville C. H., Rousseau D., Bonnafous S., Patouraux S., Adam G., Lavallard V. J., Rovere C., Le Thuc O., Saint-Paul M. C., Anty R., Schneck AS., Iannelli A., Gugenheim J., Tran A., Gual P., Bailly-Maitre B. |title=ER stress induces NLRP3 inflammasome activation and hepatocyte death |journal=Cell Death Dis |year=2015 |volume=6 |issue= |pages=e1879 |url=https://www.ncbi.nlm.nih.gov/pubmed/26355342}.}</ref> et ''NLRC4'' munerum singularium nominata sunt.
 
=== Physiologia ===
Quando [[infectio]] prodit cellulae systematis immunitatis, ut [[monocytus|monocyti]], [[macrophagocytus|macrophagocyti]] receptoria peculiaria, ''receptoria exempla cognoscendorum'' (Anglice: ''Pattern Recognition Receptors'', ''PRR'') enim, exprimunt: et superficie membranae et intra cellulam.
 
Haec ''PRR''′ia modo duo genera stimulorum cognoscunt: ''PAMP'' vel ''DAMP''. ''PAMP'' est abbreviatura Anglica "pathogenis sociatorum exemplorum molecularis" (''pathogen-associated molecular patterns''), quae sunt partes ''corpori alienae'', per exemplum lipopolysaccharidi bacteriorum. Pluribus exemplis alienis receptoria propria ex familia [[receptorium typi Toll instar|receptoriorum typi Toll instar]] (abbreviatura internationalis: ''TLR'') superficie cellulae sunt; Exemplum [[Flagellum (biologia)|flagella bacterialia]] per [[receptorium typi Toll instar 5|TLR 5]] superficie membranae cellularum immunitatis recognoscuntur<ref>{{cite journal |authors=Rumbo M., Nempont C., Kraehenbuhl J. P., Sirard J. C. |title=Mucosal interplay among commensal and pathogenic bacteria: lessons from flagellin and Toll-like receptor 5 |journal=FEBS Lett |year=2006 |volume=580 |issue=12 |pages=2976-84 |url=https://www.ncbi.nlm.nih.gov/pubmed/16650409}}.</ref>. ''DAMP'' sunt "vastitatibus sociata exempla molecularia" (''damage-associated molecular patterns''), quae sunt partes cellularum vulneratarum ''corporis poprii'' denaturatae: Quando damnum cellularum prodit, organella ex cellula liberata signum initii inflammationis fient<ref>{{cite journal |authors=Rubartelli A., Lotze M. T. |title=Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs) and redox |journal=Curr Opin Immunol |year=2007 |volume=23 |issue=5 |pages=591-7 |url=https://www.ncbi.nlm.nih.gov/pubmed/17845865}}.</ref>.
 
Inter cytokina et inflammasomata cellularum immunitatis mutuo signa dantur<ref>{{cite journal |authors=Barker B. R., Taxman D. J., Ting J. P. |title=Cross-regulation between the IL-1β/IL-18 processing inflammasome and other inflammatory cytokines |journal=Curr Opin Immunol |year=2011 |volume=23 |issue=5 |pages=591-7 |url=https://www.ncbi.nlm.nih.gov/pubmed/21839623}}.</ref>.
 
== Notae ==
 
{{NexInt}}
{{div col|32}}
* [[Apoptosis]]
* [[Caspasis]]
{{div col end}}
 
[[Categoria:Caspases]]
[[categoriaCategoria:Immunitatis systema]]
[[categoria:inflammationes]]
[[Categoria:Inflammationes]]
[[categoria:caspases]]
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