Nucleus supraopticus
Cognitores
TA: A14.1.08.912
Anatomia
Nucleus supraopticus
Sectione frontale (coronali) situs nuclei supraopticus (SON) immediate supra tractum opticum (OT) est. 3V = ventriculus tertius

Nucleus supraopticus est nucleus hypothalamicus ex tribus milibus cellularum magnocellularium compositus. Cellulae haec hormonta et vasopressinum et oxytocinum in sanguinem liberant[1]. Locatus est nucleus supraopticus in regione anteriori, immediate supra chiasma opticum.

Anatomia microscopicaRecensere

Nucleus supraopticus haud magnus apparet, ei tantum circiter tria milia neuronorum insunt. Zona perinuclearis nucleo ipso vicina est.

CircuitusRecensere

Axona nervi supraoptici in partem posteriorem hypophysis ducunt[2]:

Nucleus supraopticus → pars posterior glandulae pituitariae

Videtur ut axona nervi supraoptici etiam in organi suprafornicalis neurona terminent, quae axona in nucleum paraventricularem mittunt[3]:

Nucleus supraopticus → organum suprafornicale → nucleus paraventricularis

PhysiologiaRecensere

Cellulae haec hormon vasopressinum secernunt, quod, trans sanguinem missum, in renibus reabsorptionem natrii Na+ auget. Generant nuclei cellulae etiam hormon oxytocinum[4].

Si pressio sanguinis augeat, zona periventricularis inhibitionis neuronorum vasopressini necesse sit[5].

NotaeRecensere

  1. Hirasawa M., Mouginot D., et al. (Mai 2003). "Vasopressin differentially modulates non-NMDA receptors in vasopressin and oxytocin neurons in the supraoptic nucleus". The journal of neuroscience 23 (10): 4270-7 
  2. Kombian S.B., Hirasawa M., et al. (2002). "Modulation of synaptic transmission by oxytocin and vasopressin in the supraoptic nucleus". Progress in brain research (139): 235-46 
  3. Kawano H. (Apr 2017). "Synaptic contact between median preoptic neurons and subfornical organ neurons projecting to the paraventricular hypothalamic nucleus". Experimental brain research 235 (4): 1053-62 
  4. Takayanagi Y., Yoshida M., et al. (Feb 2017). "Synaptic contact between median preoptic neurons and subfornical organ neurons projecting to the paraventricular hypothalamic nucleus". Biological psychiatry 81 (3): 243-51 
  5. Grindstaff R. R., Cunningham J. T. (Mar 2001). "Lesion of the perinuclear zone attenuates cardiac sensitivity of vasopressinergic supraoptic neurons". American journal of physiology 280 (3): R630-8 

Nexus interni