Doxepinum

Doxepinum est substantia psychoanaleptica et antidepressiva, ergo medicamentum tractationis depressionum, praesertim cum insomnia praesente, effectu sedativo suo causa, quia Doxepinum receptorium H₁ agonista inversa^[1] obsidet. Per structuram chemicam Doxepinum est antidepressivum tricyclicum. Ceroma^[2] quoque Doxepinum therapiae pruritus^[3] et dermatitis atopicae et lichenis simplicis chronici (neurodermatitis) brevis temporis adhiberi potest.

Cave: notitiae huius paginae nec praescriptiones nec consilia medica sunt.

**Doxepinum**
Cognitores
ChemSpider	3046
PubChem	3158
DrugBank	DB01142
Natura chemica


Formula chemica	C ₁₉H ₂₁NO
Massa molaris	279.376 g/mol
Natura pharmacologica
Codex ATC	N06AA12 (WHO)
Tempus semivitae biologicum	17 (8-24) h Nor-Doxepinum: 31 h
Metabolismus	Iecore (hepaticus): CYP2D6 CYP2C19
Metabolitus	Nor-Doxepinum
Excretio	renibus (ca. 50%), faecibus: minus
Ad usum therapeuticum
Applicatio	per os, i.v., i.m.
MedlinePlus	a682390 (Anglice)

Natura Doxepini

Formula summarum est C
₁₉H
₂₁NO. Nomen IUPAC est 3-(dibenzo[b,e]oxepino-11(6H)-ylideno)-N,N-dimethylo-propano-1-aminum.

Massa molaris est 279.376 g/mol.

↑ Shiroishi M, Kobayashi T (2017). "Structural Analysis of the Histamine H1 Receptor". Handb Exp Pharmacol 241: 21-30
↑ Leppert W, Malec-Milewska M, Zajaczkowska R, Wordliczek J (2018). "Transdermal and Topical Drug Administration in the Treatment of Pain". Molecules 23 (3): pii:E681
↑ Kaur R, Sinha VR (2018). "Antidepressants as antipruritic agents: A review". Eur Neuropsychopharmacol 28 (3): 341-52