Alfentanilum

Alfentanilum est medicamentum, analgeticum opioidorum, cuius effectus sedativi haud diuturni (15 min) cum initio rapido effectuum^[2] sunt. Opioidum ipsum effectus analgeticos suos per stimulationem receptoria opioidorum perficit. Hos ob effectus Alfentanilum in chirurgia imprimis substantia anaesthetica adhibetur. Alfentanilum rigorem thoraxis intermittentem efficere potest.

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**Alfentanilum**
Natura chemica

Formula chemica	C₂₁H₃₂N₆O₃
Massa molaris	416.517 g/mol
PubChem	51263
DrugBank	DB00802
Natura pharmacologica
Codex ATC	N01AH02 (WHO)
Tempus semivitae biologicum	90-111 min
Metabolismus	iecore (hepaticus): CYP3A4^[1]
Metaboliti	Noralfentanilum (NA) N-phenylpropionamidum (AMX)
Ad usum therapeuticum
Applicatio	i.v.
MedlinePlus	a601130^{[nexus deficit]} (Anglice)

Natura Alfentanili

Natura chemica

Nomen chemicum Alfentanili est N-[1-[2-(4-ethyl-5-oxo-1,4-dihydrotetrazol-1-yl)ethyl]-4-(methoxymethyl)-4-piperidyl]-N-phenyl-propanamidum, formula summarum sua est C₂₁H₃₂N₆O₃. Massa molaris est 416.517 g/mol. Valor pKa circiter 6.5 est itaque substantia apud pH physiologicum haud electrice oneratum videtur.

Vicinitates chemicae

Alfentanili structura chemica Fentanylo et Remifentanilo similis est.

Effectus Alfentanili

Effectus adversi

Inter alios Alfentanilum rigorem thoraxis intermittentem efficere potest.

Usus Alfentanili

Usus medicus

In anaesthesiologia doses 15–30 µg/kg applicantur, quod est cum pondus 62.0^[3] kg / 136.7 lb circiter 1-2 mg applicari solere possint.

Nexus interni

Notae

↑ Labroo RB, Thummel KE, Kunze KL, Podoll T, Trager WF, Kharasch ED (1995). "Catalytic role of cytochrome P4503A4 in multiple pathways of alfentanil metabolism". Drug Metab Dispos 23 (4): 490-6
↑ Miner JR, Gray R, Delavari P, Patel S, Patel R, Plummer D (2011). "Alfentanil for procedural sedation in the emergency department". Ann Emerg Med 57 (2): 117-21 .
↑ Walpole SC, Prieto-Merino D, Edwards P, Cleland J, Stevens G, Roberts I (2012 volume=12). "The weight of nations: an estimation of adult human biomass". BMC Public Health: 439

[1] Labroo RB, Thummel KE, Kunze KL, Podoll T, Trager WF, Kharasch ED (1995). "Catalytic role of cytochrome P4503A4 in multiple pathways of alfentanil metabolism". Drug Metab Dispos 23 (4): 490-6

[2] Miner JR, Gray R, Delavari P, Patel S, Patel R, Plummer D (2011). "Alfentanil for procedural sedation in the emergency department". Ann Emerg Med 57 (2): 117-21 .

[3] Walpole SC, Prieto-Merino D, Edwards P, Cleland J, Stevens G, Roberts I (2012 volume=12). "The weight of nations: an estimation of adult human biomass". BMC Public Health: 439

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