Receptorium histamini
Receptoria histamini sunt receptoria neurotransmissoria et classis receptoriorum proteino G copulatorum cum histamino ligando endogeno[1].
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Adhuc quattuor typi receptoriorum histamini noti sunt[2]:
- Receptorium histamini H1 - Contractiones ilei, vasodilatatio, pruritus, bronchoconstrictio. Antagonista H1 receptorii: Diphenhydraminum, Loratadinum, Cetirizinum, Fexofenadinum, Clemastinum
- Receptorium histamini H2 - Stomachus: incrementum secretionis chymi. Antagonista H2 receptorii: Ranitidinum, Cimetidinum, Famotidinum, Nizatidinum
- Receptorium histamini H3 - deminutio concentrationis in cerebro Acetylcholini, Serotonini, Noradrenalini
- Receptorium histamini H4 - Chemotaxis (mastocytus)
Histaminum
recensere
Conferatur pagina principalis Histaminum.In organismis histaminum est neurotransmissor, quae signa per nervos transmittit. Praeterea in allergia histaminum pars reactionis systematis immunitatis est.
Notae
recensere- ↑ Classificatio internationalis receptorum Histamini: Hill SJ, Ganellin CR, Timmerman H, Schwartz JC, Shankley NP, Young JM, Schunack W, Levi R, Haas HL (1997). Pharmacol. Rev. 49 (3): 253–78
- ↑ Panula P., Chazot P. L., Cowart M., Gutzmer R., Leurs R., Liu W. L., Stark H., Thurmond R. L., Haas H. L. (2015). "International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors". Pharmacological reviews 67 (3): 601-55.
Receptoria histamini
