Summarium

DescriptioVirus Replication.svg	A diagram of influenza viral cell invasion and replication.
Datum	5 Martius 2007
Fons	Redrawn from w:Image:Virusreplication.png using Adobe Illustrator.
Auctor	User:YK Times
Other versions	w:Image:Virusreplication.png

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Description from Scheme of Influenza A virus replication (NCBI): "A virion attaches to the host cell membrane via HA and enters the cytoplasm by receptor-mediated endocytosis (STEP 1), thereby forming an endosome. A cellular trypsin-like enzyme cleaves HA into products HA1 and HA2 (not shown). HA2 promotes fusion of the virus envelope and the endosome membranes. A minor virus envelope protein M2 acts as a ion channel thereby making the inside of the virion more acidic. As a result, the major envelope protein M1 dissociates from the nucleocapsid and vRNPs are translocated into the nucleus (STEP 2) via interaction between NP and cellular transport machinery. In the nucleus, the viral polymerase complexes transcribe (STEP 3a) and replicate (STEP 3b) the vRNAs. Newly synthesized mRNAs migrate to cytoplasm (STEP 4) where they are translated. Posttranslational processing of HA, NA, and M2 includes transportation via Golgi apparatus to the cell membrane (STEP 5b). NP, M1, NS1 (nonstructural regulatory protein - not shown) and NEP (nuclear export protein, a minor virion component - not shown) move to the nucleus (STEP 5a) where they bind freshly synthesized copies of vRNAs. The newly formed nucleocapsids migrate into the cytoplasm in a NEP-dependent process and eventually interact via M1 with a region of the cell membrane where HA, NA and M2 have been inserted (STEP 6). Then the newly synthesized virions bud from infected cell (STEP 7). NA destroys the sialic acid moiety of cellular receptors, thereby releasing the progeny virions."

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