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[[Fasciculus:Lewy Koerperchen.JPG|right|thumb|Corpuscula Leweyi]]
'''Corpusculum Leweyi'''<ref>Tretiakoff (1919) Contribution a L’étude de L’anatomie Pathologique de Locus Niger de Soemmerling. Université de Paris, Paris. Tretiakoff corpuscula Leweyi ''Corps de Lewy'' vocavit.</ref> est aggregatio [[proteinum|proteinorum]] ([[alpha-synucleinum|alpha-synucleini]]<ref>[http://www.tandfonline.com/doi/abs/10.4161/auto.5604 De alpha-synucleino et morbo Parkinson] {{Ling|Anglice}}</ref>) morbosa intra [[cellula]]rem ad [[morbus Parkinson|morbum Parkinsonianum]] et [[dementia cum corpusculis Leweyi|dementiam cum corpusculis Leweyi]] pertinentes<ref>{{cite journal |authors=Outeiro T. F., Koss D. J., Erskine D., Walker L., Kurzawa-Akanbi M., Burn D., Donaghy P., Morris C., Taylor J. P., |title=Dementia with Lewy bodies: an update and outlook |journal=Molecular neurodegeneration |year=2019 |volume=14 |issue=1 |pages=5 |url=https://www.ncbi.nlm.nih.gov/pubmed/30665447}}</ref>, ''morbus corpusculorum Leweyi'' dictus. Morbi corpusculorum Leweyi sunt [[morbus Parkinsonianus]], [[dementia cum corpusculis Leweyi]], [[imbecillitas autonomica pura]].
== Natura corpusculorum Leweyi ==
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Corpusculum inclusionis est substantia stabilis intracellularis, quae vel intra [[cytoplasma]]te vel intra [[nucleus cellulae|nucleum]] (sive utrumque). Corpuscula Leweyi ex plus quam nonaginta [[proteinum|proteinis]], imprimis [[alpha-synucleinum|α-synucleino]], constituta sunt. Aggregatio non solum in cytoplasmate [[perikaryon|somatis]] (notione ''corpusculum Leweyi'' sensu strictu) sed etiam in [[neuritum|neurito]] (notione ''neuritum Leweyi'') fit.
Notio ''morbi corpusculorum Leweyi'' ad spectrum morborum diversorum cum diffusione corpusculorum Leweyi late in [[systema nervosum]] refert. Exempla sunt [[morbus Parkinsonianus]], [[dementia cum corpusculis Leweyi]], [[imbecillitas autonomica pura]]. Omnes cum ''perturbationibus gastrointestinalibus'' coniuncti sunt, ut scientia novissime [[systema nervosum entericum]] investigat. Inter effectus ibidem videtur, ut textus oesophagi progressum morbi indicet<ref>{{cite journal |authors=Tanei Z.-I., Saito Y., et al. |title=Lewy pathology of the esophagus correlates with the progression of Lewy body disease: a Japanese cohort study of autopsy cases |journal=Acta neuropathologica |year=2021 |month=Ian |volume=141 |issue=1 |pages=25-37 |url=https://pubmed.ncbi.nlm.nih.gov/33150517/}}</ref>.
=== Corpora Leweyi et morbus Parkinson ===
In morbo Parkinson corpusculis Leweyi plus quam nonaginta producta genorum insunt<ref>{{cite journal |authors=Wakabayashi K., Tanji K., et al. |title=The Lewy body in Parkinson's disease and related neurodegenerative disorders |journal=Molecular neurobiology |year=2013 |month=Apr |volume=47 |issue=2 |pages=495-508 |url=https://pubmed.ncbi.nlm.nih.gov/22622968/}}</ref>, ut [[alpha-synucleinum]], DJ-1, LRKK2, ''parkin'', mitochondrialis ''[[PTEN inducta kinasis 1]]'' (PINK-1), at etiam [[mitochondrium|''mitochondriorum'']] [[enzymum|enzyma]], molecula ''systematis ubiquitini et proteasomatum'', ''autophagiae'', formationis aggresomatum. PINK-1 mitochondria protegit. ''[[Aggresoma]]ta'' sunt proteinorum non recte plicatorum aggregationes.
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