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'''Sclerosis lateralis amyotrophica'''<ref>[http://www.researchgate.net/publication/34151928_ber_Sclerosis_lateralis_amyotrophica__inaugural-Dissertation_welche_zur_Erlangung_der_Doctorwrde_in_der_Medicin_und_Chirurgie_mit_Zustimmung_der_medicinischen_Facultt_der_Friedrich-Wilhelms-Universitt_zu_Berlin_am_23._Juli_1895_nebst_den_angefgten_Thesen_ffentlich_vertheidigen_Wird_ Dissertatio,] www.researchgate.net.</ref> ([[ICD-10]]: G12.2) est gravis [[neurodegeneratio|morbus systematis nervosi]], accurate [[neuron|neuronum]] [[motus|motoriorum]] defectio. Hic [[morbus]], qui [[corpus]] [[morbus degenerativus|degenerat]] dum progreditur, adhuc hodie [[sanatio|sanari]] non potest, et ad extremum in [[mors|mortem]] ducit. Primum hunc morbum descripsit [[Ioannes Martinus Charcot]], [[medicus]] [[Francia|Francicus]].
In [[Italia]] multi [[pedilusor]]es hoc morbo mortui sunt, ergo putatur, scilicetut etiamfortasse [[venenum|venena]] contra mala [[gramen|gramina]] adhibita, quae in pediludii campis utuntur, sclerosem lateralem amyotrophicam generare possuntpossint.<ref>M. Vinceti, I. Bottecchi, A. Fan, Y. Finkelstein, J. Mandrioli (2012): Are environmental exposures to selenium, heavy metals, and pesticides risk factors for amyotrophic lateral sclerosis? In: Rev Environ Health, vol. 1, pp. 19-41.</ref> Non est remediaremedium plenasanans, at ad morbum allevandi,allevandum inter alia [[technologia adiuvans]] vel [[communicatio augmentans et alternativa]] uteturutitur.{{dubsig}}
== Symptomata et signa ==
Neuronibus motoriorum degeneratismotoriis et superioribus et inferioribus degeneratis [[symptoma]]ta ac signa [[musculus|musculorum]] et tenuitas (atrophia) et infirmitas corporis apparent. Cum initium nonhaud rareraro obscureobscurum essetest, in morbi cursu symptomata muscularia progredianturprogrediuntur. Adhuc omnibus rationibus infrenata,infrenatis postremo morbus quamcumque paene gubernationem motuum voluntariam affert, quamquam etaufert. [[vesica urinaria|vesicae]] et tractūs gastrointestinalis et [[musculusMusculus externus bulbi oculi|musculorumMusculorum bulbi oculi externorum]] gubernatio autem saepe usque ad extremum intacta restabitrestat sicut et functio [[Musculus levis|musculorum levium]] in tractibus [[Tractus gastrointestinalis|gastrintestinali]] et [[Tractus urogenitalis|urogenoitali.<ref>{{cite journal |authors=Hobson E. V., McDermott C. J. |title=Supportive and symptomatic management of amyotrophic lateral sclerosis |journal=Nat Review of Neurology |year=2016 |volume=12 |pages=526-38 |url=https://www.ncbi.nlm.nih.gov/pubmed/27514291}}.</ref>.
Nuper sclerosem lateralem amyotrophicam etiam symptomata obstringere prospectatum est. Symptomata psychiatrica ut [[schizophrenia]]e vel [[perturbatio affectionis mentis|mali affectionis]] iam descripta sunt<ref>{{cite journal |authors=Zucchi E., Ticozzi N., Mandrioli J. |title=Psychiatric Symptoms in Amyotrophic Lateral Sclerosis: Beyond a Motor Neuron Disorder |journal=Frontiers in neuroscience |year=2019 |volume=13 |pages=175 |url=https://www.ncbi.nlm.nih.gov/pubmed/30914912}}</ref>. Porro nexus cum [[degeneratio lobularis frontotemporalis|degeneratione lobulari frontotemporali]] suspicatus est.
== Neuropathologia ==
DecursuAd gradus morbi definienda [[proteinum]] [[TDP-43]] momentum maiusaliquantum haberevalere videtur<ref>{{cite journal |authors=Brettschneider J., Del Tredici K., Toledo J. B., Robinson J. L., Irwin D. J., Grossman M., Suh E., Van Deerlin V. M., et al. |title=Stages of pTDP-43 pathology in amyotrophic lateral sclerosis |journal=Annals in neurology |year=2013 |volume=74 |issue=1 |pages=20-38 |url=https://www.ncbi.nlm.nih.gov/pubmed/23686809}}</ref>.
== Tractatio ==
Adhuc methodus curandi incognitusincognita est. In therapia hodierna medicamentum [[Riluzolum]] adhiberi licet, quod decursum paulum tardat<ref>{{cite journal |authors=Miller R. G., Mitchell J. D., Moore D. H. |title=Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND) |journal=The Cochrane database of systematic reviews |year=2012 |month=Mar |issue=3 |pages=)CD001447 |url=https://www.ncbi.nlm.nih.gov/pubmed/22419278}}</ref>.
== Homines notabiles affecti ==
*[[Stephanus Borgonovo]] ([[1964]]–[[2013]])
*[[Stanislaus Gross]] ([[1969]]–[[2015]])
*[[Georgius Immendorf]] ([[1945]]-[[2007]])
*[[Stephanus Hawking]] ([[1942]]-[[2018]])
== Nexus externi ==
{{CommuniaCat|Amyotrophic lateral sclerosis|Sclerosem lateralem amyotrophicam}}
* [httpshttp://www.dmozninds.orgnih.gov/Healthdisorders/Conditions_and_Diseases/Neurological_Disorders/Amyotrophic_Lateral_Sclerosisamyotrophiclateralsclerosis/detail_ALS.htm National Institute of Neurological Disores an Stroke:De Sclerose laterali amyotrophica] {{Ling|Anglice}}
* [http://www.ninds.nih.gov/disorders/amyotrophiclateralsclerosis/detail_ALS.htm De Sclerose laterali amyotrophica]{{Ling|Anglice}}
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