Quantum redactiones paginae "Serotoninum" differant
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[[Fasciculus:5-HT Neuron.svg|thumb|Serotonini biosynthesis, imminutio et effectus moleculares in rima synaptica]]
'''Serotoninum''' seu '''5-hydroxytryptaminum''' ('''5-HT''') sive '''enteraminum''' est [[hormon]], accurate [[indolaminum]], quod cum [[dopaminum|dopamino]], [[noradrenalinum|noradrenalino]] et [[adrenalinum|adrenalino]] ad complexum [[monoaminum|monoaminorum]] pertinet. In corpore a multis membris ([[iecur|iecore]], [[lien]]e, [[systema nervosum|systemate nervoso centrali]]) effunditur.
== Biochemia ==
[[Fasciculus:Serotonin biosynthesis.svg|thumb|[[Synthesis biologica]]. Serotoninum cum [[hydroxylatio|hydroxylatione]] [[tryptophanum|tryptophani]] tum [[decarboxylatio|decarboxylatione]] [[5-hydroxytryptophanum|5-hydroxytryptophani]] fit [[reactio chemica|reactionibus chemicis]] duobus, utrisque propium [[enzymum]] attributum est. [[Denominatio internationalis communis|Denominationen internationalem communem]] (''INN'') 5,6,7,8-tetrahydrobiopterini [[sapropterinum]] esse notetur.]]
=== Synthesis biochemica ===
[[Synthesis biologica]] serotonini gradibus duobus accidit, primo [[hydroxylatio|hydroxylatione]] [[tryptophanum|tryptophani]] deinde [[decarboxylatio|decarboxylatione]] [[5-hydroxytryptophanum|5-hydroxytryptophanum]].
==== Tryptophani hydroxylasis (tryptophanum) ====
[[Tryptophanum]] [[acidum aminicum]] est substantia initialis. In [[enzymum|enzymi]] [[tryptophani hydroxylasis]]<ref>{{cite journal |authors=Boularand S, Darmon MC, Ganem Y, Launay JM, Mallet J |title=Complete coding sequence of human tryptophan hydroxylase |journal=Nucleic Acids Res |year1990 |month=iul |volume=18 |pages=4257 |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC331198/ }}</ref> praesentia tryptophano gregem hydroxidi (-OH, [[oxygenium]] cum [[hydrogenium|hydrogenio]]) additur. [[Enzymum]] [[tryptophani hydroxylasis]] ([[TPH1]] et -solum in [[cerebrum|cerebro]]- [[TPH2]]) cum [[cofactor (biochemia)|cofactore]] Fe<sup>++</sup> in communione cum [[sapropterinum|sapropterino]] et [[oxygenium|oxygenio]] (O<sub>2</sub>) aliud [[acidum aminicum]] chemicum, quod [[5-hydroxytryptophanum]] nominatur, format.
==== Decarboxylasis acidorum aminicorum aromaticorum (5-hydroxytryptophanum) ====
[[5-hydroxytryptophanum]] tunc [[decarboxylasis acidorum aminicorum aromaticorum|decarboxylasi acidorum aminicorum aromaticorum]] [[carbonii dioxidum]] (CO<sub>2</sub>) reddit, ideo structura [[acidum aminicum|acidi aminici]] sua perdit. Substantia chemia nova est 5-hydroxytryptaminum, sive serotoninum.
== Notae ==
<references />
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== Nexus externus ==
* [http://mrel.beckman.uiuc.edu/sweedler/serotonin.html De serotonini catabolismo]
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