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Linea 4: Clastogenum in [[biologia]] fracturas in [[chromosoma]]tibus efficere potest, quo facto, sectiones chromosomatis deleri, addi, vel commutari possunt. Haec ratio est genus [[mutagenesis]], quod ad [[carcinogenesis\|carcinogenesin]] ducere potest, quia [[cellula]]e ab effectu clastogenico non necatae canceraticae fieri possunt. Inter clastogena nota sunt [[flavus acridinus]], [[benzenum]], [[oxidum ethyleni]], [[arsenicum]], [[phosphinum]], et [[mimosinum]]. Exponi clastogenis [[numerus\|numerum]] cellularum germinarum<!--germ-->{{dubsig}} abnormium in [[mas\|maribus]] paternalibus auget, effectus evolutionis in [[fetus\|fetu]] post [[~~fertilizatio~~fecundatio]]nem adiuvans. Sententia inlustrans: :[[Chemia]] quae responsum significantem in obrussa clastogenicitatis [[in vitro]] non inducit non verisimilis est clastogenicam esse [[in vivo]] in obrussis medullae [[os (ossis)\|ossium]].<ref>[[Anglice]]: "A chemical that fails to induce a significant response in an ''in vitro'' clastogenicity assay is unlikely to be clastogenic ''in vivo,'' in bone marrow assays."—John Rose, [http://books.google.com/books?id=5lMP9ivOoxcC&pg=PA64&dq=Clastogenic&lr= ''Environmental Toxicology: Current Developments''] (1988:64).</ref>

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